581 – Establishment of Folfox-Induced Sinusoidal Obstruction Syndrome Model in Microminipig
نویسندگان
چکیده
منابع مشابه
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model
BACKGROUND & AIMS Sinusoidal obstruction syndrome (SOS) following oxaliplatin based chemotherapy can have a significant impact on post-operative outcome following resection of colorectal liver metastases. To date no relevant experimental models of oxaliplatin induced SOS have been described. The aim of this project was to establish a rodent model which could be utilised to investigate mechanism...
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BACKGROUND Sinusoidal obstruction syndrome (SOS), a form of drug-induced liver injury related to oxaliplatin treatment, is associated with postoperative morbidity after hepatectomy. This study aimed to examine the impact of regorafenib, the first small-molecule kinase inhibitor to show efficacy against metastatic colorectal cancer, on a rat model of SOS. METHODS Rats with monocrotaline (MCT)-...
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(1) Duplicates amon (2) Duplicate public journals; Editor: Giovanni Tarantino. Received: April 5, 2015; revised: May 4, 2015; accepted: May 6, 2015. From the Department of Gastroenterology, General, Hospital of Shenyang Military Area (XW, XQ, XG); and Postgraduate College, Liaoning University of Traditional Chinese Medicine (XW), Shenyang, China. Correspondence: Prof Xiaozhong Guo, MD, PhD, and...
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چکیده ندارد.
Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy
Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or “blue liver syndrome”, is a commonly recognized vascular pattern of drug-induced liver injury, and has been frequently associated wit...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2019
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)40003-6